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NEMBUTAL® Sodium Solution (pentobarbital sodium) Injection, USP

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DESCRIPTION The barbiturates are nonselective central nervous system depressants that are primarily used as sedative-hypnotics and also anticonvulsants in sub hypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See "Drug Abuse and Dependence" section).

The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions.

Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance that has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.

NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10%, and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.

NEMBUTAL (pentobarbital) Sodium is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methyl butyl) barbiturate. The structural formula for pentobarbital sodium is:

NEMBUTAL® (Pentobarbital Sodium) Structural Formula Illustration The sodium salt occurs as a white, slightly bitter powder that is freely soluble in water and alcohol but practically insoluble in benzene and ether.

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